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GLP-1 & MetabolicSynthetic GLP-1 receptor analog
Semaglutide
$39.99
5 mg· 4 strengths availableSemaglutide is a synthetic analog of glucagon-like peptide-1 (GLP-1), a gut-derived signaling peptide. Structural modifications, including fatty-acid acylation, extend its half-life relative to native GLP-1, which is why it is frequently selected as a stable reference agonist in laboratory work.
Researchers use it to investigate GLP-1 receptor activation, downstream cyclic-AMP signaling, and incretin-related metabolic pathways in cell and preclinical models.
Research areas
GLP-1 receptor signalingIncretin biologyMetabolic pathway researchPreclinical research
Form: Lyophilized (freeze-dried)
- Compound class
- Synthetic GLP-1 receptor analog
- Research category
- GLP-1 & Metabolic
- SKU
- NVR-SEMAGLUTIDE-5MG
- Alternate name
- Sema
- CAS
- 910463-68-2
- Appearance
- White to off-white lyophilized powder
- Storage
- Store lyophilized at −20 °C. Protect from light and moisture.
Research use only
Select strength
Cost per mg shown for each option
1
$39.99per 5 mg$8.00/mg
For research use only — not for human or animal consumption.
Supplied solely for legitimate laboratory and research purposes. Not for medical or veterinary use, diagnosis, treatment, or prevention of disease.
Research Grade
Batch Documentation
Research Use Only
U.S.-Based Fulfillment
What you should know
More detail on Semaglutide.
Analytical values reflect per-lot documentation and appear once a batch is released.
Compound
Semaglutide belongs to the incretin-mimetic class of peptides. The GLP-1 receptor is a G-protein-coupled receptor expressed in pancreatic islet tissue and several other cell types, and its activation is commonly measured through cyclic-AMP accumulation in receptor assays. Because semaglutide resists rapid enzymatic degradation, investigators often use it where prolonged receptor occupancy is needed across an experimental time course. Published laboratory research examines receptor binding characteristics, signaling bias, and comparative activity against native GLP-1 and other analogs. All work with this material is experimental and conducted in vitro or in preclinical models.
Peptide class
Synthetic GLP-1 receptor analog
Mechanism (research context)
Semaglutide is a GLP-1 receptor agonist. Structural modifications — including an Aib substitution at position 8 and a fatty-acid side chain — reduce enzymatic degradation and enable albumin binding in preclinical models.
Why it is studied
Semaglutide is one of the most extensively studied long-acting GLP-1 analogs in current metabolic pharmacology literature.
Current areas of research
GLP-1 receptor signalingIncretin biologyMetabolic pathway researchPreclinical research
Topics reflect published preclinical and in vitro research. Reference only — not a claim of clinical outcomes.
Scientific background
The GLP-1 analog series originated with exendin-based research and has evolved through liraglutide to semaglutide, each generation extending functional half-life.
Semaglutide represents one of the most cited long-acting GLP-1 analog research peptides.
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