5-Amino-1MQ
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Small-molecule NNMT inhibitor used as a chemical probe in adipocyte and methylation research.
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Anti-Aging & LongevityMitochondrial-derived peptide (16 amino acids)
MOTS-C
$59.99
10 mg· 3 strengths availableMOTS-c is a 16-amino-acid peptide encoded within the mitochondrial genome rather than nuclear DNA — one of a small group of mitochondrial-derived peptides identified in the past two decades.
Research interest centers on its reported role in AMPK-associated signaling and its function as a signal transmitted from mitochondria to the rest of the cell, including the nucleus.
Research areas
Mitochondrial-derived peptidesAMPK signalingMetabolic homeostasis researchPreclinical research
Form: Lyophilized (freeze-dried)
- Compound class
- Mitochondrial-derived peptide (16 amino acids)
- Research category
- Anti-Aging & Longevity
- SKU
- NVR-MOTS-C-10MG
- Alternate name
- MOTSc
- Appearance
- White lyophilized powder
- Storage
- Store lyophilized at −20 °C. Protect from light and moisture.
Research use only
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$59.99per 10 mg$6.00/mg
For research use only — not for human or animal consumption.
Supplied solely for legitimate laboratory and research purposes. Not for medical or veterinary use, diagnosis, treatment, or prevention of disease.
Research Grade
Batch Documentation
Research Use Only
U.S.-Based Fulfillment
What you should know
More detail on MOTS-C.
Analytical values reflect per-lot documentation and appear once a batch is released.
Compound
The discovery that mitochondrial DNA encodes short bioactive peptides opened a distinct line of cell-biology research, and MOTS-c is among the most studied examples. Published in vitro work links it to AMPK pathway activity and to folate–methionine cycle metabolites, and reports have described nuclear translocation under metabolic stress. Laboratory applications include metabolic-signaling assays, mitochondrial stress-response models, and studies of retrograde mitochondria-to-nucleus communication. The field is comparatively young and mechanistic detail continues to develop.
Peptide class
Mitochondrial-derived peptide (16 amino acids)
Mechanism (research context)
MOTS-c has been studied in cellular systems for effects on metabolic pathways associated with AMPK signaling and glucose metabolism.
Why it is studied
MOTS-c is one of the earliest characterized mitochondrial-derived peptides and remains a reference compound in the MDP research field.
Current areas of research
Mitochondrial-derived peptidesAMPK signalingMetabolic homeostasis researchPreclinical research
Topics reflect published preclinical and in vitro research. Reference only — not a claim of clinical outcomes.
Scientific background
MOTS-c was identified in 2015 by researchers at the University of Southern California, drawing attention to short open reading frames within mitochondrial DNA as a source of bioactive peptides.
Subsequent literature has expanded characterization of MOTS-c and other MDPs in metabolic and aging research.
Related
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MOTS-C
10 mg · $59.99