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Anti-Aging & LongevitySmall molecule (isoquinoline derivative)
5-Amino-1MQ
$49.99
10 mg· 2 strengths available5-Amino-1MQ is a small molecule rather than a peptide — a methylquinolinium compound that acts as an inhibitor of nicotinamide N-methyltransferase (NNMT).
NNMT consumes both nicotinamide and the methyl donor S-adenosylmethionine, so inhibiting it is a way for researchers to probe methylation flux and NAD+ salvage chemistry in cultured cells, particularly in adipocyte models where the enzyme is highly expressed.
Research areas
NNMT enzyme inhibitionAdipocyte metabolismMethylation flux studiesNAD+ salvage pathway
Form: Lyophilized (freeze-dried)
- Compound class
- Small molecule (isoquinoline derivative)
- Research category
- Anti-Aging & Longevity
- SKU
- NVR-5-AMINO-1MQ-10MG
- Alternate name
- 5A1MQ
- Appearance
- White to off-white crystalline solid
- Storage
- Store lyophilized at −20 °C. Protect from light and moisture.
Research use only
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$49.99per 10 mg$5.00/mg
For research use only — not for human or animal consumption.
Supplied solely for legitimate laboratory and research purposes. Not for medical or veterinary use, diagnosis, treatment, or prevention of disease.
Research Grade
Batch Documentation
Research Use Only
U.S.-Based Fulfillment
What you should know
More detail on 5-Amino-1MQ.
Analytical values reflect per-lot documentation and appear once a batch is released.
Compound
NNMT sits at an intersection of two metabolic currencies: the methyl-donor pool and the nicotinamide pool feeding NAD+ salvage. Because it depletes both when active, selective inhibition is a useful experimental lever. 5-Amino-1MQ emerged from published inhibitor screens as a chemically simple, cell-permeable option and is now a common probe in metabolic cell biology. Investigators typically use DMSO stocks diluted into culture medium and include selectivity controls against related methyltransferases. Its use is limited to in vitro laboratory research.
Peptide class
Small molecule (isoquinoline derivative)
Mechanism (research context)
In vitro studies characterize 5-Amino-1MQ as a substrate-competitive NNMT inhibitor. Inhibition of NNMT preserves intracellular nicotinamide and S-adenosylmethionine pools, which researchers use to probe methylation flux and NAD+ salvage pathways in cultured cells.
Why it is studied
The compound is commonly used as a chemical probe for NNMT biology because it is orally bioavailable in preclinical models and selective for NNMT over related methyltransferases.
Current areas of research
NNMT enzyme inhibitionAdipocyte metabolismMethylation flux studiesNAD+ salvage pathway
Topics reflect published preclinical and in vitro research. Reference only — not a claim of clinical outcomes.
Scientific background
NNMT was identified as an enzyme upregulated in adipose tissue and several tumor lineages in the early 2000s, generating interest in selective inhibitors as research tools.
5-Amino-1MQ emerged from published NNMT inhibitor screens as a chemically tractable scaffold with in vitro activity in the low-micromolar range. Subsequent literature has characterized its selectivity and in-cell activity.
Current laboratory investigation focuses on how NNMT inhibition modulates methyl-donor availability, one-carbon metabolism, and downstream metabolic phenotypes in preclinical models.
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5-Amino-1MQ
10 mg · $49.99