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MelanocortinSynthetic cyclic heptapeptide (α-MSH analog)

Melanotan II

$49.99

10 mg

Melanotan II is a cyclic lactam heptapeptide analog of alpha-MSH. Cyclization constrains the peptide's conformation, increasing stability and potency relative to the linear hormone.

Unlike more selective analogs, it engages multiple melanocortin receptor subtypes, which makes it useful in laboratory research as a broad reference agonist when mapping activity across the receptor family.

Research areas

Melanocortin receptor pharmacologyCyclic peptide designReceptor selectivity studiesPreclinical research

Form: Lyophilized (freeze-dried)

Compound class: Synthetic cyclic heptapeptide (α-MSH analog)
Research category: Melanocortin
SKU: NVR-MELANOTAN-II-10MG
Alternate name: MT2
CAS: 121062-08-6
Appearance: White lyophilized powder
Storage: Store lyophilized at −20 °C. Protect from light and moisture.

Research use only

Strength

10 mg$49.99$5.00/mg

$49.99per 10 mg$5.00/mg

For research use only — not for human or animal consumption.

Supplied solely for legitimate laboratory and research purposes. Not for medical or veterinary use, diagnosis, treatment, or prevention of disease.

Research Grade

Batch Documentation

Research Use Only

U.S.-Based Fulfillment

What you should know

More detail on Melanotan II.

Analytical values reflect per-lot documentation and appear once a batch is released.

Compound

Conformational constraint through cyclization is a standard strategy in peptide chemistry, and Melanotan II is a frequently cited example of it applied to the melanocortin scaffold. Its non-selective profile is a feature in comparative pharmacology: running it alongside subtype-preferring analogs helps define selectivity windows in receptor assays. Laboratory applications include cyclic-AMP measurement across MC1R through MC5R expressing cell lines, structure–activity studies, and preclinical models examining melanocortin signaling. Supplied for laboratory research only.

Peptide class

Synthetic cyclic heptapeptide (α-MSH analog)

Mechanism (research context)

MT2 is a non-selective agonist at melanocortin receptors and is used in the receptor-pharmacology literature to probe MC1R, MC3R, MC4R, and MC5R signaling.

Why it is studied

It is a foundational research compound in melanocortin-receptor pharmacology, used across pigmentation, appetite-signaling, and receptor-selectivity studies.

Current areas of research

Melanocortin receptor pharmacologyCyclic peptide designReceptor selectivity studiesPreclinical research

Topics reflect published preclinical and in vitro research. Reference only — not a claim of clinical outcomes.

Scientific background

Melanotan II was developed in the 1980s at the University of Arizona as a superpotent α-MSH analog with a cyclic structure conferring receptor stability.

It has since become one of the most cited melanocortin-agonist research tools.

Batch number

Batch documentation will be added when inventory is released.

Purity

≥ 98% (per lot documentation, when available)

Analytical method

RP-HPLC & mass spectrometry (per lot documentation)

Testing laboratory

Independent third-party analytical laboratory

Batch documentation will be added when inventory is released. Once a batch is released, its analytical records and Certificate of Analysis are linked here. Requests: grant@novarynresearch.com.

Research Grade

Batch Documentation Where Available

Laboratory Handling Guidance

Laboratory Use Only

Laboratory concentration calculator

Use the selected research-material amount and your chosen total liquid volume to calculate laboratory concentration.

Material amount

10 mgSelected

From the selected Melanotan II strength.

Total liquid volume

Mathematical laboratory concentration calculation only. This tool does not provide preparation recommendations of any kind.

Calculations are a laboratory reference for in vitro work only. No preparation, administration, or human-use guidance is provided.

Storage

Store lyophilized at −20 °C. Protect from light and moisture.

Form

Lyophilized (freeze-dried) powder

Shipping conditions

Ships from the United States in packaging appropriate to the product's storage requirements. Cold-chain packaging is used where required.

Handling recommendations

Handle per institutional laboratory protocols. Wear appropriate PPE, minimize exposure to light and moisture, and record lot information on the working aliquot.

Product name

Melanotan II

Peptide class

Synthetic cyclic heptapeptide (α-MSH analog)

Research category

Melanocortin

Size

10 mg — $49.99

Appearance

White lyophilized powder

Delivery form

Lyophilized (freeze-dried) powder

CAS number

121062-08-6

Molecular formula

C₅₀H₆₉N₁₅O₉

Molecular weight

1024.18 g/mol

Purity specification

≥ 98% (per lot documentation, when available)

Solubility

Soluble in bacteriostatic water

Storage temperature

Store lyophilized at −20 °C. Protect from light and moisture.

Shelf life

24 months lyophilized under recommended storage

Laboratory use

For in vitro research use only. Not for human or veterinary use.

Alternate names

MT2 · MT-II · Melanotan 2

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No — PT-141 (bremelanotide) is a distinct compound derived from the MT2 series but with different receptor selectivity.

Lyophilized materials are typically reconstituted with bacteriostatic water. Follow institutional protocols and consult the applicable batch documentation when available.

Materials ship in insulated packaging appropriate to their handling requirements. Cold-chain packaging is used where required by the product's storage guidance.

Batch-specific documentation, including a Certificate of Analysis, is provided when available for the released lot. Contact grant@novarynresearch.com for outstanding requests.