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Recovery & StructuralSynthetic thymosin β4 fragment

TB-500

$59.99

5 mg· 2 strengths available

TB-500 is a synthetic peptide corresponding to an active region of thymosin beta-4, a naturally occurring actin-sequestering protein.

Its research interest centers on actin dynamics: thymosin beta-4 binds monomeric G-actin and influences the balance between free and polymerized actin, making the fragment a useful tool in cytoskeletal and cell-motility research.

Research areas

Actin binding and cytoskeletal dynamicsCell migration researchStructural biologyPreclinical research

Form: Lyophilized (freeze-dried)

Compound class: Synthetic thymosin β4 fragment
Research category: Recovery & Structural
SKU: NVR-TB-500-5MG
Alternate name: TB500
CAS: 77591-33-4
Appearance: White lyophilized powder
Storage: Store lyophilized at −20 °C. Protect from light and moisture.

Research use only

Select strength

Cost per mg shown for each option

$59.99per 5 mg$12.00/mg

For research use only — not for human or animal consumption.

Supplied solely for legitimate laboratory and research purposes. Not for medical or veterinary use, diagnosis, treatment, or prevention of disease.

Research Grade

Batch Documentation

Research Use Only

U.S.-Based Fulfillment

What you should know

More detail on TB-500.

Analytical values reflect per-lot documentation and appear once a batch is released.

Compound

The actin-binding domain of thymosin beta-4 is compact enough to be synthesized directly, and TB-500 represents that region. Because actin polymerization underlies cell shape, migration, and division, a peptide that shifts the G-actin pool is a practical laboratory probe for those processes. Published research examines migration and wound-closure assays in cultured cells, cytoskeletal reorganization, and comparisons with full-length thymosin beta-4. Mechanistic work continues, and investigators should treat the fragment as a research tool rather than a characterized therapeutic entity.

Peptide class

Synthetic thymosin β4 fragment

Mechanism (research context)

Published research characterizes thymosin β4 fragments in actin-regulation, cell-migration, and angiogenesis models. TB-500 is used as a defined-sequence reference in this literature.

Why it is studied

TB-500 is a widely cited synthetic fragment used in tissue-repair and cell-migration research, frequently paired with BPC-157 in preclinical protocols.

Current areas of research

Actin binding and cytoskeletal dynamicsCell migration researchStructural biologyPreclinical research

Topics reflect published preclinical and in vitro research. Reference only — not a claim of clinical outcomes.

Scientific background

Thymosin β4 was first isolated in the 1960s from thymus tissue. Its role as an intracellular actin-binding peptide became a central topic of cytoskeletal-biology research in subsequent decades.

TB-500 corresponds to a fragment of the full sequence and has become one of the most cited synthetic thymosin-β4-derived research peptides.

Batch number

Batch documentation will be added when inventory is released.

Purity

≥ 98% (per lot documentation, when available)

Analytical method

RP-HPLC & mass spectrometry (per lot documentation)

Testing laboratory

Independent third-party analytical laboratory

Batch documentation will be added when inventory is released. Once a batch is released, its analytical records and Certificate of Analysis are linked here. Requests: grant@novarynresearch.com.

Research Grade

Batch Documentation Where Available

Laboratory Handling Guidance

Laboratory Use Only

Laboratory concentration calculator

Use the selected research-material amount and your chosen total liquid volume to calculate laboratory concentration.

Material amount

5 mgSelected

From the selected TB-500 strength.

Total liquid volume

Mathematical laboratory concentration calculation only. This tool does not provide preparation recommendations of any kind.

Calculations are a laboratory reference for in vitro work only. No preparation, administration, or human-use guidance is provided.

Storage

Store lyophilized at −20 °C. Protect from light and moisture.

Form

Lyophilized (freeze-dried) powder

Shipping conditions

Ships from the United States in packaging appropriate to the product's storage requirements. Cold-chain packaging is used where required.

Handling recommendations

Handle per institutional laboratory protocols. Wear appropriate PPE, minimize exposure to light and moisture, and record lot information on the working aliquot.

Product name

TB-500

Peptide class

Synthetic thymosin β4 fragment

Research category

Recovery & Structural

Available sizes

5 mg — $59.99 10 mg — $79.99

Appearance

White lyophilized powder

Delivery form

Lyophilized (freeze-dried) powder

CAS number

77591-33-4

Molecular formula

C₂₁₂H₃₅₀N₅₆O₇₈S

Molecular weight

≈ 4963.4 g/mol

Purity specification

≥ 98% (per lot documentation, when available)

Solubility

Soluble in bacteriostatic water

Storage temperature

Store lyophilized at −20 °C. Protect from light and moisture.

Shelf life

24 months lyophilized under recommended storage

Laboratory use

For in vitro research use only. Not for human or veterinary use.

Alternate names

TB500 · Thymosin Beta-4 fragment

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TB-500 corresponds to a defined fragment of the full thymosin β4 sequence, not the entire 43-amino-acid protein.

Lyophilized materials are typically reconstituted with bacteriostatic water. Follow institutional protocols and consult the applicable batch documentation when available.

Materials ship in insulated packaging appropriate to their handling requirements. Cold-chain packaging is used where required by the product's storage guidance.

Batch-specific documentation, including a Certificate of Analysis, is provided when available for the released lot. Contact grant@novarynresearch.com for outstanding requests.