Hover to zoom

Growth Hormone ResearchRecombinant analog of insulin-like growth factor 1

IGF-1 LR3

$79.99

1 mg

IGF-1 LR3 is a recombinant analog of insulin-like growth factor 1 carrying an arginine substitution at position 3 and a 13-residue N-terminal extension.

Those changes sharply reduce its affinity for IGF binding proteins, which is the specific property that makes it valuable in cell-culture research: more of the added peptide remains free to engage the IGF-1 receptor rather than being sequestered by binding proteins present in serum.

Research areas

IGF-1 receptor signalingCell-culture researchBinding-protein interaction studiesPreclinical research

Form: Lyophilized (freeze-dried)

Compound class: Recombinant analog of insulin-like growth factor 1
Research category: Growth Hormone Research
SKU: NVR-IGF-1-LR3-1MG
Alternate name: IGF1
Appearance: White lyophilized powder
Storage: Store lyophilized at −20 °C. Protect from light and moisture.

Research use only

Strength

1 mg$79.99$79.99/mg

$79.99per 1 mg$79.99/mg

For research use only — not for human or animal consumption.

Supplied solely for legitimate laboratory and research purposes. Not for medical or veterinary use, diagnosis, treatment, or prevention of disease.

Research Grade

Batch Documentation

Research Use Only

U.S.-Based Fulfillment

What you should know

More detail on IGF-1 LR3.

Analytical values reflect per-lot documentation and appear once a batch is released.

Compound

IGF binding proteins complicate quantitative work with native IGF-1 because they buffer free peptide concentration in unpredictable ways. LR3 was engineered to sidestep that problem and is now a routine supplement in serum-free and low-serum culture systems. Research applications include studying IGF-1 receptor activation and downstream PI3K/Akt and MAPK signaling, examining proliferation and differentiation in cultured cell lines, and quantifying the contribution of binding proteins by comparing LR3 with native IGF-1. Laboratory research use only.

Peptide class

Recombinant analog of insulin-like growth factor 1

Mechanism (research context)

In cell-culture research, IGF-1 LR3 shows extended functional activity relative to native IGF-1 because it interacts less strongly with the IGFBP family, leaving more free peptide available for receptor engagement.

Why it is studied

It is a standard research reagent in cell-culture media for stem-cell, myoblast, and growth-factor studies where extended IGF-1 signaling is desired.

Current areas of research

IGF-1 receptor signalingCell-culture researchBinding-protein interaction studiesPreclinical research

Topics reflect published preclinical and in vitro research. Reference only — not a claim of clinical outcomes.

Scientific background

IGF-1 LR3 was developed as a research analog to overcome the binding-protein sequestration that limits native IGF-1 activity in culture systems.

It has become one of the most cited IGF reagents in cell-culture literature, particularly for extended-signaling experimental designs.

Batch number

Batch documentation will be added when inventory is released.

Purity

Batch documentation will be added when inventory is released.

Analytical method

RP-HPLC & mass spectrometry (per lot documentation)

Testing laboratory

Independent third-party analytical laboratory

Batch documentation will be added when inventory is released. Once a batch is released, its analytical records and Certificate of Analysis are linked here. Requests: grant@novarynresearch.com.

Research Grade

Batch Documentation Where Available

Laboratory Handling Guidance

Laboratory Use Only

Laboratory concentration calculator

Use the selected research-material amount and your chosen total liquid volume to calculate laboratory concentration.

Material amount

1 mgSelected

From the selected IGF-1 LR3 strength.

Total liquid volume

Mathematical laboratory concentration calculation only. This tool does not provide preparation recommendations of any kind.

Calculations are a laboratory reference for in vitro work only. No preparation, administration, or human-use guidance is provided.

Storage

Store lyophilized at −20 °C. Protect from light and moisture.

Form

Lyophilized (freeze-dried) powder

Shipping conditions

Ships from the United States in packaging appropriate to the product's storage requirements. Cold-chain packaging is used where required.

Handling recommendations

Handle per institutional laboratory protocols. Wear appropriate PPE, minimize exposure to light and moisture, and record lot information on the working aliquot.

Product name

IGF-1 LR3

Peptide class

Recombinant analog of insulin-like growth factor 1

Research category

Growth Hormone Research

Size

1 mg — $79.99

Appearance

White lyophilized powder

Delivery form

Lyophilized (freeze-dried) powder

CAS number

Batch documentation will be added when inventory is released.

Molecular formula

Batch documentation will be added when inventory is released.

Molecular weight

Batch documentation will be added when inventory is released.

Purity specification

≥ 98% (per lot documentation, when available)

Solubility

Batch documentation will be added when inventory is released.

Storage temperature

Store lyophilized at −20 °C. Protect from light and moisture.

Shelf life

24 months lyophilized under recommended storage

Laboratory use

For in vitro research use only. Not for human or veterinary use.

Alternate names

IGF1 · Long R3 IGF-1 · LR3

Subscribe & Save

Every 30 days · 10% off · Every 60 days · 15% off · Every 90 days · 20% off

It carries an R3 substitution and an N-terminal 13-amino-acid extension that reduce IGF-binding protein affinity.

Lyophilized materials are typically reconstituted with bacteriostatic water. Follow institutional protocols and consult the applicable batch documentation when available.

Materials ship in insulated packaging appropriate to their handling requirements. Cold-chain packaging is used where required by the product's storage guidance.

Batch-specific documentation, including a Certificate of Analysis, is provided when available for the released lot. Contact grant@novarynresearch.com for outstanding requests.